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Is there an isomorphism between the interior of $[0,1]$ and $[0,1]$?
I feel stupid for asking this question, but... I would assume that this is true. I'm just not 100% sure.
A:
No.
The interior of $[0,1]$ is simply $\{x\in[0,1]: x
ot\in\varnothing\}$. Since $[0,1]$ is closed, it has no interior.
Methylation of kinesin spindle protein is a frequent event in non-small cell lung cancer.
Kinesin spindle protein (KSP) was recently described as a novel therapeutic target in tumor therapy. Previously, we showed in an exon array analysis that in lung cancer cells, the expression of the KSP gene was significantly reduced and linked to an increase in DNA methylation. These findings prompted us to determine the methylation status of the KSP gene in non-small cell lung cancer (NSCLC) tissues. The methylation status of the KSP gene was analyzed by methylation-specific PCR (MSP) in 39 surgically resected NSCLC specimens and 10 pulmonary adenocarcinoma cell lines. The expression of KSP mRNA in the NSCLC tissues was also analyzed by semiquantitative RT-PCR. KSP gene was found to be unmethylated in 10 of 39 (26%) NSCLC tissue samples, but all (100%) 10 pulmonary adenocarcinoma cell lines. The semiquantitative RT-PCR analysis of KSP mRNA revealed that the level of KSP mRNA in the lung cancer tissues was significantly decreased compared with the control lung tissues, and it was negatively correlated with the methylation status of KSP gene. In conclusion, our results show that the KSP gene is frequently methylated in NSCLC tissues. The reduction of KSP expression in tumor tissues is likely to be a consequence of the hypermethylation of the 0b46394aab
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